TPU-based antiplatelet cardiovascular prostheses prepared using fused deposition modelling

• 3D-printing was used to prepare TPU vascular grafts loaded with dipyridamole. samples containing 5% dipyridamole showed antiplatelet properties. higher drug loadings did not show The similar mechanical properties previously described grafts. resulting 3D-printed were hemocompatible. Samples stimulated HUVEC cell proliferation. This work describes the use of fused deposition modelling (FDM) thermoplastic polyurethane (TPU)-based tubular FDM technology is widely available and provides ability easily design on demand, enabling customisation prosthesis dimensions. An drug, (DIP), combined using hot-melt extrusion filaments. DIP cargos ranged between 5 20% (w/w). filaments small diameter FDM. These characterised. Moreover, release kinetics, activity in vitro hemo- cytocompatibility evaluated. results suggested that materials could provide sustained for 30 days. presence material a clear effect compared pristine TPU. Alternatively, resulted surface roughness leading platelet adhesion. Therefore, biocompatibility tested showing this type allowed proliferation samples. Finally, rifampicin-loaded double-layered demonstrated antimicrobial against both Staphylococcus aureus Escherichia coli.